BDBM50118213 5'-UTP::CHEMBL336296::H4utp::UTP::uridine 5'-(tetrahydrogen triphosphate)::uridine 5'-triphosphoric acid

SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O

InChI Key InChIKey=PGAVKCOVUIYSFO-XVFCMESISA-N

Data  2 KI  1 IC50  59 EC50

PDB links: 128 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50118213   

TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human P2Y4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human P2Y4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  88nMAssay Description:Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  480nMAssay Description:Agonist activity at human P2Y purinoceptor 4 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human GFP-tagged P2Y4 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  87nMAssay Description:Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  73nMAssay Description:Agonist activity at human recombinant P2Y4 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  2.50E+3nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  2.60E+3nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled recombinant rat P2Y purinoceptor 4 (P2Y4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  100nMAssay Description:Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y4 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human cloned P2Y4 receptor expressed in human 1321N1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human cloned P2Y4 receptor expressed in human 1321N1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  480nMAssay Description:Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50118213(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Affinity DataEC50:  550nMAssay Description:Agonist activity at human P2Y4 transfected in human 1321N1 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed